Volume 2, Issue 2, December 2019, Page: 15-18
A 19 Month Old Male Child with Xeroderma Pigmentosum-A Case Report
Md. Shohidul Islam Khan, Department of Pediatrics, 250 Bedded Hospital, Moulvibazar, Bangladesh
Shamima Jahan, Department of Pediatrics, 250 Bedded Hospital, Moulvibazar, Bangladesh
Sompa Rani Paul, Department of Pediatrics, 250 Bedded Hospital, Moulvibazar, Bangladesh
Mohammad Morshad Alam, Department of Pediatrics, Sadar Hospital, Laxmipur, Bangladesh
Muhammad Ismail Hasan, Department of Pediatrics, Sadar Hospital, Laxmipur, Bangladesh
Dhiman Chowdhury, Department of Pediatrics, Chattogram Medical College Hospital, Chattogram, Bangladesh
Kamrunnaher Shultana, Department of Pediatrics and PICU, Square Hospitals Ltd., Dhaka, Bangladesh
Farhana Zerin Khan, Department of Pediatric Surgery, Square Hospitals Ltd., Dhaka, Bangladesh
Md. Mozammel Haque, Department of Pediatrics, 250 Bedded Hospital, Moulvibazar, Bangladesh
Received: Nov. 19, 2019;       Accepted: Dec. 6, 2019;       Published: Dec. 11, 2019
DOI: 10.11648/j.ijcd.20190202.12      View  518      Downloads  92
Abstract
Background: Xeroderma Pigmentosum (XP) is a rare autosomal recessive genodermatosis characterized by pigmentary abnormalities, solar skin damage and cutaneous malignancies on sun exposed area of skin and eyes. XP occurs in subjects with molecular defects in the genes involved in nucleotide excision repair (NER) of ultraviolet-induced DNA lesions leading to premature skin and ocular ageing consequent upon cellular apoptosis and other UV-induced degenerative changes. If sufficient DNA damage occurs, there will be cellular transformation and the development of malignancies. Both genetic, as well as environmental factor, play an important role in XP. XP has a >1000-fold increased risk of a cutaneous basal cell or squamous cell carcinoma or malignant melanoma. Case history: In this case report, we mentioned about a 19 month old boy who was diagnosed clinically as a case of Xeroderma Pigmentosum and presented with pigmentary skin changes (generalized hypo and hyper pigmented macule), eye problems, developmental delay, acute respiratory infection and failure to thrive. A multidisciplinary team involving the Pediatrician, Dermatologist and Ophthalmologist evaluated, diagnosed and treated the patient. In this case, XP was diagnosed clinically due to lack of all investigation facilities. This genetic premalignant condition is rarely diagnosed at the district level hospitals in Bangladesh. We report this case to upgrade the knowledge of pediatricians working in the rural areas (primary and secondary level health care facilities) regarding the diagnosis, counseling, treatment modalities and appropriate referral for Xeroderma Pigmentosum. Recommended management should be focused on educating the patient and the parents about effective sun protection and early recognition of cancers. Genetic counseling should be offered for families at risk
Keywords
Genetic, Premalignant, Xeroderma Pigmentosum
To cite this article
Md. Shohidul Islam Khan, Shamima Jahan, Sompa Rani Paul, Mohammad Morshad Alam, Muhammad Ismail Hasan, Dhiman Chowdhury, Kamrunnaher Shultana, Farhana Zerin Khan, Md. Mozammel Haque, A 19 Month Old Male Child with Xeroderma Pigmentosum-A Case Report, International Journal of Clinical Dermatology. Vol. 2, No. 2, 2019, pp. 15-18. doi: 10.11648/j.ijcd.20190202.12
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reference
[1]
Feller L, Wood NH, Motswaledi MH, Khammissa RAG, Meyer M, LemmerJ. Xeroderma Pigmentosum: a case report and review of the literature. J prev med hyg. 2010; 51: 87-91.
[2]
Genetic Home Reference. Xeroderma Pigmentosum; [accessed 6th December 2019]. Available from: https://ghr.nlm.nih.gov/condition/xeroderma-pigmentosum#statistics.
[3]
Up To Date. Xeroderma Pigmentosum; [updated 1st August 2019; accessed 6th December 2019]. Available from: https://www.uptodate.com/contents/xeroderma-pigmentosum.
[4]
Uribe-Bojanini E, Hernandez-Quiceno S, Cock-Rada AM. Xeroderma Pigmentosum with severe neurological manifestations/De Sanctis–Cacchione syndrome and a novel XPC mutation. Case Reports in Medicine. 2017; Article ID 7162737.
[5]
Wikipedia. Xeroderma Pigmentosum; [updated 4th December 2019; accessed 6th December 2019]. Available from: https://en.wikipedia.org/wiki/Xeroderma_pigmentosum.
[6]
Choudhary S, Parakh M, Suthar K, Parakh P, Khichar S. A noncancerous variant of Xeroderma Pigmentosum type D associated with novel heterozygous missense ERCC2 gene mutation. Indian J Dermatol Venereol Leprol. 2017; 83: 594-95.
[7]
Brooks BP, Thompson AH, Bishop RJ, Clayton JA, Chan CC, Tsilou ET, et al. Ocular manifestations of Xeroderma Pigmentosum: long term follow-up highlights the role of DNA repair in protection from sun damage. Ophthalmology. 2013; 120 (7): 1324–336.
[8]
Medscape. Neurologic Manifestations of Xeroderma Pigmentosum Clinical Presentation; [updated 19th March 2019; accessed 6thDecember 2019]. Available from: https://emedicine.medscape.com/article/1177889-clinical.
[9]
Kalogaa M, Diousséb P, Diattac BA, Bammod M, Kouroumaa S, Diabatee A, et al. Squamous cell carcinoma in African children with Xeroderma Pigmentosum: three case reports. Case Rep Dermatol. 2016; 8: 311–18.
[10]
Odhiambo AO, Kaminja K, Munyao T. Suspected case of stage 3 Xeroderma Pigmentosum: a case report. Afr JHaematol Oncol. 2015; 5: 15-18.
[11]
Pandey AN, Kuldeep K, Koul A, Tyagi M, Singh P, Sharma PD, et al. Xeroderma Pigmentosum with ocular association: case report. Case Reports in Clinical Medicine. 2013; 2 (8): 466-69.
[12]
Mulimani SM, Talikoti DG. A child with Xeroderma Pigmentosum for excision of basal cell carcinoma. Saudi J Anaesth. 2013; 7 (4): 467–69.
[13]
Medscape. Xeroderma Pigmentosum Workup; [updated 10th June 2016; accessed 6th December 2019]. Available from: https://emedicine.medscape.com/article/1119902-workup.
[14]
Kleijer WJ, van der Sterre ML, Garritsen VH, Raams A, Jaspers NG. Prenatal diagnosis of Xeroderma Pigmentosum and Trichothiodystrophy in 76 pregnancies at risk. Prenat Diagn. 2007; 27 (12): 1133-137.
[15]
Therapeutics in Dermatology. Xeroderma Pigmentosum; [updated 4th March 2019; accessed 6th December 2019]. Available from: https://www.therapeutique-dermatologique.org/spip.php?article1566.
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